De novo design of cysteine proteases

De novo design of cysteine proteases

Radzicka, A. & Wolfenden, R. Uncatalyzed peptide bond hydrolysis rates in neutral solution and transition state affinities of proteases. J. Am. Chemistry. Soc. 118, 6105–6109 (1996). Article ADS CAS Google Scholar Dyer, RP & Weiss, GA Making the cut with protease engineering. Cellular chemistry. Biol. 29, 177–190 (2022). CAS Article PubMed Google Scholar Otto, H.-H. … Read more

Early tetrapod neck mobility modelled using an extant analogue

Early tetrapod neck mobility modelled using an extant analogue

Arratia, G., Schultze, H.-P. & Casciotta, J. Vertebral column and associated elements in dipnoans and comparison with other fishes: development and homology. J. Morphol. 250, 101–172 (2001).Article  PubMed  CAS  Google Scholar  Coates, M. The Devonian tetrapod Acanthostega gunnari Jarvik: postcranial anatomy, basal tetrapod interrelationships and patterns of skeletal evolution. Trans. R. Soc. Edinb. 87, 363–421 … Read more

Warning to women amid shortages of some HRT products – BBC

Warning to women amid shortages of some HRT products - BBC

Warning to women amid shortages of some HRT products BBCGeneric medicines manufacturers ramp up patch supply to meet demand Chain Drug ReviewMore women turn to hormone therapy to manage menopause transition, leading to shortage of estrogen patches Camas-Washougal Post-RecordPharmacists told to ration THIS medication amid national shortage Glasgow TimesCan’t find your estrogen patch? Here’s what … Read more

UK economy grew 0.1% in August, beating expectations

UK economy grew 0.1% in August, beating expectations

The UK economy grew a better-than-expected 0.1% in the month to August, with output growth offsetting weak output in services and construction. Economists polled by Reuters expected GDP to contract 0.1% between July and August. But the reading still marked a slowdown in momentum for Britain’s gross domestic product, which grew 0.4% month-on-month in June … Read more

US considering using ‘Mother of All Bombs’ against Iran, sources say

US considering using ‘Mother of All Bombs’ against Iran, sources say

The U.S. military has developed new attack plans that include potentially using the so-called “mother of all bombs” to attack Iranian energy infrastructure and nuclear sites should President Donald Trump give the order to resume combat operations before or after the midterm elections, according to several U.S. officials familiar with the matter. Using the GBU-43/B … Read more

North Korea and China open new bridge after 12-year delay

North Korea and China open new bridge after 12-year delay

“Whereas just a decade ago, Beijing openly criticized the nuclearization of North Korea – and in fact called for the denuclearization of Pyongyang – now China says little or nothing about it,” Edward Howell, a professor at the University of Oxford, tells the BBC.

iPhone Duo’s A20 Pro Chip Benchmarked Ahead of Launch

Apple Says iPhone Duo Has Replaceable 'Cover Layer'

As expected, the iPhone Duo offers similar performance to the iPhone 18 Pro, according to one of the first iPhone Duo benchmarks shared on Geekbench 7. Both devices are equipped with Apple’s 2nm A20 Pro chip with a 6-core CPU and a 7-core GPU. The tested ‌iPhone Duo‌ (iPhone19,4) runs iOS 27.1, as expected, and … Read more

Jackson Chourio hits first-pitch home run in NLCS Game 3

Jackson Chourio hits first-pitch home run in NLCS Game 3

LOS ANGELES — Brewers budding superstar Jackson Chourio wasted no time wowing the Dodger Stadium crowd. Chourio crushed the first pitch of Game 3 of the National League Championship Series, a 97.6 mph four-seam center cutter from Dodgers left-hander Blake Snell, for a home run to right-center in Wednesday’s 6-2 victory. He scored the 17th … Read more