Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion

Targeting ZMYND8 unleashes IL-2 signalling to override T cell exhaustion

MiceC57BL/6, P14 TCR-transgenic (Tg)45, pmel TCR-Tg46 and Rosa26-Cas9 knock-in47 mice were purchased from the Jackson Laboratory. Human CD19 CAR-Tg mice were provided by T. Geiger36. We crossed Rosa26-Cas9 knock-in mice with P14, pmel or human CD19 (hCD19) CAR-Tg mice to express Cas9 in antigen-specific CD8+ T cells. The Cas9-expressing mice were fully backcrossed to the … Read more

Trump, Xi to talk Taiwan, AI, trade, Iran in D.C. summit

Trump, Xi to talk Taiwan, AI, trade, Iran in D.C. summit

President Donald Trump and Chinese leader Xi Jinping are expected to meet at the White House on Thursday for high-stakes talks on trade, artificial intelligence and the Iran war, amid displays of military fanfare and a lavish banquet. While China analysts broadly predict that the leaders’ personal relationship and political goals will result in a … Read more

Florida governor candidate Byron Donalds stands by Trump after some mentions of the president removed from website

Florida governor candidate Byron Donalds stands by Trump after some mentions of the president removed from website

Some prominent references to President Trump were removed from Florida gubernatorial candidate Byron Donalds’ campaign website in recent weeks, but the Republican said Wednesday that he will not stray from the president’s agenda. During an onstage interview at the Sunshine Economy Summit, Donalds said his campaign has “been working on website changes for about two … Read more

Anthropic CEO Dario Amodei says AI could cure most diseases in 5-10 years

Anthropic CEO Dario Amodei says AI could cure most diseases in 5-10 years

Impact3 co-founder Kyle Reidhead discusses the future of the artificial intelligence revolution and investment opportunities in AI infrastructure in ‘Making Money’. Anthropic CEO Dario Amodei predicted on Wednesday that AI could help cure most diseases in the next five to 10 years, arguing that the advanced technology will change the way scientists study biology and … Read more

Nikon unveils Z5IIC camera, aimed at making photography less intimidating

Nikon unveils Z5IIC camera, aimed at making photography less intimidating

Nikon has announced its new Nikon Z5IIC, a full-frame mirrorless camera for people who want to get into photography but don’t know where to start. Designed for ease of use, the Z5IIC promises point-and-shoot performance that produces great images straight from the camera, while offering manual controls to accommodate creators’ growing skills. SEE ALSO: Best … Read more

The streak is over: Sounders finally win

The streak is over: Sounders finally win

SEATTLE – The Seattle Sounders ended their winless streak on Wednesday night, beating Real Salt Lake 2-0. Second-half goals from Danny Musovski (48′) and Albert Rusnák (73′), and Andrew Thomas’ seventh clean sheet of the season secured the result for Seattle and ended a winless streak. The first half was as boring as a football … Read more

Deadly predators, colossal giants and animals visible from space: 20 ocean record breakers that will boggle your mind

Deadly predators, colossal giants and animals visible from space: 20 ocean record breakers that will boggle your mind

The ocean covers more than 70 percent of our planet and remains largely unknown and unexplored. However, within its deep trenches and sunlit coral reefs lie creatures of unimaginable scale and power. Whether you’re wondering which beast dominates the deepest waters or what kind of creature has enough venom to cast 26 in minutes, these … Read more

mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis

mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis

hPS cell cultureDerivation, maintenance and differentiation of human pluripotent stem cell lines was approved by the University of California, Berkeley Stem Cell Research Oversight Committee (protocol no. 2014-10-029). WIBR3 hES cells (National Institutes of Health (NIH) stem cell registry 0079) were initially obtained from R. Jaenisch’s laboratory62. WIBR3 hES cell lines were cultured according to … Read more

Oil prices rise sharply as investors seek progress on U.S.-Iran talks

Oil prices rise sharply as investors seek progress on U.S.-Iran talks

Numerous merchant ships belonging to Iran and other countries remain anchored in the Strait of Hormuz in Bandar Abbas, Iran, on September 8, 2026. Fatemeh Bahrami | Anadolu | Getty Images Oil prices extended gains early Thursday amid little evidence that talks between the United States and Iran were showing progress toward a diplomatic solution … Read more