Even those not on the West Coast might be a little more interested in making Week 2 NFL picks between the Rams or 49ers. How those teams respond after playing in Australia last week will be closely watched. Both are fortunate to have home games on the NFL’s Week 2 schedule: San Francisco will host Miami on Sunday and Los Angeles will host the Giants on Monday. The Niners are 13.5-point favorites for their competition, which is the biggest spread in the NFL in the young season. Claim Polymarket’s latest promo code, CBSSPORTS, to get a $50 bonus after $10 in trades: Week 2 NFL odds also have the Rams as heavy favorites, as they’re giving the Giants 7 points, and Big Blue gets back-to-back primetime dates. This pair of matchups are among the six games with a line of at least one touchdown, as the first week clearly swayed bettors. All of the updated NFL Week 2 lines are listed below, and SportsLine’s advanced computer model has all the NFL betting tips and NFL predictions you need to make the best NFL Week 2 picks now. The model, which simulates every NFL game 10,000 times, has gone up more than $7,000 per $100 players on betting sites on top-rated NFL picks since its inception. The model enters Week 2 of the 2026 NFL season on a 53-39 streak on top-rated picks dating back to 2024. Anyone who followed its picks on NFL betting sites could have seen strong returns. Now, you’ve turned your attention to the latest Week 2 NFL odds and NFL betting lines and set betting picks for every NFL matchup. Head here to see each pick. Top Week 2 NFL Predictions We can tell you that one of the model’s strongest NFL Week 2 picks for the best betting apps is the Seahawks (-4, 41) covering at Arizona in Sunday’s 4:25 pm ET kickoff. Seattle prevailed in the Opening Game last Wednesday, and the Seahawks are 6-1 against the spread when holding a bye advantage since the start of the 2025 season. Not that the reigning champions need any additional rest, or even QB Sam Darnold (out), against Arizona, as the Seahawks have beaten the Cardinals in nine straight games, going 8-1 ATS over this stretch. The Cardinals were impressive in defeating the Chargers in Week 1, but the Cardinals still showed their flaws as their 111 penalty yards were the second-most in Week 1. The Seahawks are predicted to cover the spread nearly 60% of the time at an A-rated pick. See which other teams to pick here. New to sports trading? Visit our Kalshi promo code review and get a $25 bonus after $25 or more in trades with Kalshi promo code CBSSPORTS: Another one of your NFL Week 2 predictions: The Buccaneers (-8.5, 41.5) cover against the Browns, as Tampa is predicted to cover in over 50% of simulations. Perhaps no team looked worse in Week 1 than Cleveland, as the Browns allowed 34 points to Jacksonville, saw Deshaun Watson get sacked five times and managed just one garbage-time touchdown against the reserves. The Bucs were disappointed with a loss in Cincy, but a return home should help, as Cleveland’s 4-14 ATS road mark since 2024 is the worst record in the NFL. The model also has Over hitting more than 60% of the time. See what other equipment to choose here. How to Make NFL Week 2 Picks The model also made the call on who wins and covers in all the other games on the NFL Week 2 schedule and just revealed an underdog who wins outright by a touchdown, potentially netting him a big payday. You can only get all the picks for each game at SportsLine. So which Week 2 NFL picks can you confidently make and which underdog should you lock on to now? Check out the latest NFL odds below, then visit SportsLine to see which teams are winning and covering the spread, all from a tested computer model that has returned more than $7,000, and find out. Week 2 NFL Betting Odds, Lines, Spreads and Scores Get Week 2 NFL Picks at SportsLine
