A massive search effort is underway after a medical plane with six people on board disappeared near Nantucket while flying from Bermuda to Boston early Saturday, according to the U.S. Coast Guard and the Federal Aviation Administration. The Coast Guard told CBS News Boston in a statement Saturday night that the search would “continue overnight until further notice.” Four of the people on board are Canadian, according to Steve MacKinnon, Canada’s Minister of Transportation. “My thoughts are with everyone who was on board, as well as their families, loved ones and colleagues during this incredibly difficult time,” MacKinnon said in a statement. “We are closely monitoring the situation and working with relevant authorities as search and rescue efforts continue.” The FAA lost contact with the plane around 1 a.m. local time and issued a Search and Rescue Alert Notice for the Gulfstream G-100. The search was underway off the coast of Nantucket, according to the U.S. Coast Guard Northeast District. The Coast Guard described the extensive resources involved in the search, including an HC-144 Ocean Sentry aircraft, an HC-130 Hercules aircraft, an MH-60 Jayhawk helicopter, a 47-foot motor lifeboat and the FRC William Sparling, a Sentinel-class fast response cutter. The plane is registered to Canada-based Latitude Air Ambulance, according to the tail number provided by the US Coast Guard. The plane took off around 11:40 p.m. ET on Friday, according to data from FlightAware. Bermuda airport operator Skyport said in a statement to The Associated Press that the plane departed Bermuda’s LF Wade International Airport overnight to fly to Massachusetts. The Canadian-registered air ambulance plane had four crew members and two passengers on board. The Bermuda government said in X that they have been in contact with the families of those on board. “We are praying that all six people are found safe and thank the search and rescue teams for their continued efforts,” said Premier David Burt. It disappeared after about 1 hour and 45 minutes in the air. FlightAware data shows it fell quickly from about 24,000 feet to 11,000 feet before losing contact. The plane was scheduled to land at Boston Logan International Airport around 1:30 a.m. local time. More from CBS News Go deeper with The Free Press in: