The Washington Commanders and San Francisco 49ers will close out Week 6 on “Monday Night Football,” with kickoff scheduled for 8:15 p.m. ET at Levi’s Stadium in Santa Clara, California. Commanders head coach Dan Quinn faces increasing pressure after a 1-3-1 start to the season, as Washington looks to bounce back after a baffling error by quarterback Jayden Daniels in overtime, which resulted in a tie, rather than a potential winning kickoff opportunity. Goal.AdvertisementThe 49ers enter Monday night as one of three remaining undefeated teams in the league with a 5-0 record, following an impressive road victory over their NFC West rival and defending Super Bowl champion Seattle Seahawks. Quarterback Brock Purdy is playing at an MVP level despite injuries to his receiving corps, with 1,196 passing yards, 13 touchdowns and 2 interceptions in his first five games. He has received only one sack all year. Follow Yahoo Sports for live updates, highlights and more as the San Francisco 49ers host the Washington Commanders to close out Week 6 on “Monday Night Football” on ABC and ESPN. Live Updates5 Mon, Oct 19, 2026 11:57 pm UTC Ryan Young Mon, Oct 19, 2026 11:45 pm UTC Kate Magdziuk The Washington Commanders made several roster moves ahead of Monday night’s matchup with the San Francisco 49ers, including placing starting running back Jacory Croskey-Merritt on injured reserve with a groin injury. That will force Croskey-Merritt to miss the next four games, with a possible return against the Cincinnati Bengals in Week 11; the Commanders have a bye in Week 7. Croskey-Merritt currently leads the team with 67 carries this season for 239 rushing yards and two touchdowns, adding another 40 yards through the air. He’s coming off his best game of the season, averaging 7.5 yards per carry against the New York Giants last week, when he aggravated the groin issue he first suffered in training camp. That leaves the Commanders with backs Rachaad White, Austin Ekeler and Jeremy McNichols to carry the load for the time being with Croskey-Merritt out. Monday, October 19, 2026, 11:30 pm UTC Point Spread: 49ers -7.5Moneyline Odds: 49ers -400, Commanders +315Point Total: Over/Under 51.5Monday, October 19, 2026 11:15 pm UTC Maybe they’re convincing us of something that seems too obvious because Daniels ran nine times for 103 yards last week in his return from an elbow injury in Dallas, but also had 69 yards on seven carries in one half. that Sunday afternoon. Without a traditional running back, Daniels will need to be a big part of the running game. The 49ers did well in their only matchup with a mobile quarterback this season, but Malik Willis doesn’t have the same big-play ability as Daniels. The last time San Francisco defensive coordinator Raheem Morris faced Daniels was in the quarterback’s rookie season, and Morris had no answers at the time; It was the only other time the Commanders quarterback rushed for more than 100 yards. We’ll be happy with 40 yards of scrambles on Monday night. Check out the rest of our best bets as the Commanders take on the 49ers on “Monday Night Football,” including our pick against the spread. Mon, Oct 19, 2026 10:48 pm UTC With less than 90 minutes until the Commanders and 49ers tip off, each team has announced their Week 6 inactives. Here’s a look: Inactive Commanders Inactive 49ers
