The Week 0 college football schedule will take place on Saturday, August 29, beginning in Ireland before concluding in Las Vegas. There are eight games involving FBS teams on the slate, two of which are outliers when looking at the Week 0 college football odds. No. 14 USC is the only ranked team in action, as it is a 38.5-point favorite over San Jose State, while Florida State is a 31.5-point favorite over New Mexico State. The other six games have single-digit college football spreads, as you have different options for making college football bets. Visit our DraftKings promo code review and get $200 in bonus bets as a new user after $5+ in bets here:UNC vs. TCU (-7.5) kicks off the 2026 college football season when Bill Belichick’s Tar Heels take on the Horned Frogs in Dublin, Ireland. Another intriguing contest has FCS power North Dakota State, which has won 10 championships at that level, making its FBS debut as the Bison (-6.5) host the JSU Gamecocks. Before locking in any Week 0 college football picks, be sure to check out the latest college football predictions from SportsLine’s proven model. The model simulates each FBS game 10,000 times. He is on a 31-19 streak on top-rated CFB moneyline picks since the 2024 season, and has been upgraded for the 2026 season to have an even better factor in the transfer portal. Anyone who followed their college football betting selections at sportsbooks and betting sites could have made strong profits. Now, he’s turned his attention to the latest college football odds for Week 0 and set picks for every FBS matchup. Head here to see all the selections. New to sports trading? Visit our Kalshi promo code review and get a $25 bonus after $25 or more in trades with the Kalshi promo code CBSSPORTS: Top College Football Predictions for Week 0 One of the top college football picks the model recommends for Week 0: Virginia (-5.5, 53.5) covers against NC State in a 3:30 pm ET kickoff. UVA’s 9 ATS wins last year were second only to national runner-up Miami in the ACC. The Cavs should enjoy this game being moved from Rio de Janeiro to Virginia, considering NC State’s road problems. The Wolfpack went 0-4 ATS as a road underdog in 2025, making them the only Power 4 team to fail to cover as a road dog for at least four games. Add in that NC State is also on a 0-4 ATS streak in season openers, while the Cavs are 6-1 ATS in their last seven season openers against unranked squads, and the model has UVA covering more than 50% of the time. Another Week 0 prediction: New Mexico State (+31.5, 53.5) goes on the road and covers Florida State. FSU begins this season on a negative note, as it went 2-7 in its final nine games of 2025, not only outright but also versus the spread. The team then added QB Ashton Daniels in the offseason, who hopes the third school will be the charm after struggles at Stanford and Auburn. Daniels is 5-18 as a starter and has the fourth-worst passer efficiency (116.5) in FBS since 2023. Meanwhile, NMST has covered three straight games as an underdog and is 5-2 ATS in its last seven when the other team is the favorite. The Aggies cover almost 70% of the simulations and the Under are correct more than 50% of the time. See what other selections the model likes here. How to Make College Football Picks for Week 0 The model has also decided who wins and covers each Week 0 college football game, including an underdog it says will win outright. You can only get all the picks for each game at SportsLine. So which college football picks can you make with confidence and which underdog pulls off a shocking upset? Check out the latest college football odds below, then visit SportsLine to see which teams are winning and covering the spread, all from a proven computer model that has a 31-19 streak, and find out. College Football Odds for Week 0 See the complete Week 0 college football picks, odds and predictions here Saturday, August 29 (odds subject to change) North Carolina vs. TCU (-7.5, 47.5) San Jose State at USC (-38.5, 60.5) North Carolina State at Virginia (-5.5, 53.5) Jacksonville State at North Dakota State (-6.5, 46.5) Sacramento State at Eastern Michigan (-9.5, 52.5) New Mexico State at Florida State (-31.5, 53.5) Hawaii at Stanford (-3.5, 48.5) Memphis at UNLV (-5.5, 56.5)
