NFC West rivals and Super Bowl contenders meet when the San Francisco 49ers take on the Los Angeles Rams in a season-opening matchup in Melbourne, Australia, on Thursday. Los Angeles and San Francisco are tied for second place in the division at 12-5 in 2025. The Rams are looking to reach their third Super Bowl in nine seasons, and their first since winning Super Bowl LVI during the 2021 season. Meanwhile, the 49ers are looking to reach their third Super Bowl in eight seasons. Aaron Donald did not travel to Australia because his return to the Rams will have to wait. New to sports trading? Visit our Kalshi promo code review and get $25 bonus after $25 or more in trades with Kalshi promo code CBSSPORTS: Kick-off is at 8:35 pm ET from Melbourne Cricket Ground. The latest odds for 49ers vs. Rams have Los Angeles as a 3.5-point favorite, while the over/under for total points scored is 48.5. LA is at -198 on the money line (risk $198 to win $100). The Rams were the league’s best ATS at 12-5 last season, with the Niners at 10-6-1. Before making any choice between 49ers and Rams, be sure to see what Micah Roberts has to say. Roberts has worked in the Las Vegas sports betting industry for more than 20 years, including a 13-year stint as chief book officer of Station Casinos. Armed with an elaborate network of sources, Roberts moved to the other side of the counter and now offers unique insights across multiple sports. He begins this season with a 19-5 streak on picks involving the 49ers, returning between $1,350 and $100 to players at NFL betting sites. Anyone who followed their selections on betting sites could have made huge profits. Now, Roberts has focused on 49ers vs. Rams. You can head over to SportsLine now to see their picks. Here are several NFL odds and betting lines for Rams vs. 49ers: Spread of 49ers vs. Rams. Rams -3,549ers vs. Rams over/under 48.5 points. 49ers vs. Money Line user after $5+ in bets here: Top 49ers Vs Predictions Rams Roberts leans over 48.5 points combined for over or under bets on betting apps. The Rams and 49ers had top-10 offenses a year ago. Los Angeles finished first in total yards with 394.6 yards per game and in points average with 30.5. Meanwhile, San Francisco was seventh in total yards with 351.4 and 10th in points with 25.7. The Rams’ Matthew Stafford was the league’s Most Valuable Player, throwing for more than 4,700 yards and 46 touchdowns with just eight interceptions. San Francisco is led by veterans Brock Purdy at quarterback and Christian McCaffrey at running back. Purdy appears to be healthy after playing nine games, throwing for 2,167 yards and 20 touchdowns. He was eliminated 10 times. McCaffrey remains a dual threat. He led the 49ers in rushing and receiving in 2025. He carried 311 times for 1,202 yards and 10 touchdowns, while catching 102 passes for 924 yards and seven scores. See which team to root for at SportsLine. How to Make 49ers vs. Rams Picks Roberts has also found a crucial X-factor that makes a stretch side a must. See what’s on at SportsLine. Who wins Rams vs. 49ers on Thursday and what X factor makes one side of the spread hit hard? Visit SportsLine now to see which side of the 49ers-Rams spread you need to jump on, all from the expert who has returned between $1,350 and $100 to players in his last 24 San Francisco 49ers picks, and find out.
